Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode Xe Hyperpolarizers

نویسندگان

  • Panayiotis Nikolaou
  • Aaron M. Coffey
  • Kaili Ranta
  • Laura L. Walkup
  • Brogan M. Gust
  • Michael J. Barlow
  • Matthew S. Rosen
  • Boyd M. Goodson
  • Eduard Y. Chekmenev
چکیده

We present a systematic, multiparameter study of Rb/Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ NMR detection was used to study the dynamics of Xe polarization as a function of SEOP-cell operating temperature, photon flux, and xenon partial pressure to maximize Xe polarization (PXe). PXe values of 95 ± 9%, 73 ± 4%, 60 ± 2%, 41 ± 1%, and 31 ± 1% at 275, 515, 1000, 1500, and 2000 Torr Xe partial pressure were achieved. These PXe polarization values were separately validated by ejecting the hyperpolarized Xe gas and performing low-field MRI at 47.5 mT. It is shown that PXe in this high-pressure regime can be increased beyond already record levels with higher photon flux and better SEOP thermal management, as well as optimization of the polarization dynamics, pointing the way to further improvements in hyperpolarized Xe production efficiency.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers

We present a systematic, multiparameter study of Rb/(129)Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ NMR detection was used to study the dynamics of (129)Xe polarization as a function of SEOP-cell operating temperature, photon flux, and xenon partial pressure to maximize (12...

متن کامل

Temperature-Ramped 129Xe Spin-Exchange Optical Pumping

We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode (129)Xe hyperpolarizer utilizing three key temperature regimes: (i) "hot"-where the (129)Xe hyperpolarization rate is maximal, (ii) "warm"-where the (129)Xe hyperpolarization approaches unity, and (iii) "cool"-where hyperpolarized (129)Xe gas is transferred into a Tedlar bag with lo...

متن کامل

Configuration and Performance of a Mobile 129Xe Polarizer

A stand-alone, self-contained and transportable system for the polarization of (129)Xe by spin exchange optical pumping with Rb is described. This mobile polarizer may be operated in batch or continuous flow modes with medium amounts of hyperpolarized (129)Xe for spectroscopic or small animal applications. A key element is an online nuclear magnetic resonance module which facilitates continuous...

متن کامل

Theory of spin - exchange optical pumping of 3 He and 129 Xe

We present a comprehensive theory of nuclear spin polarization of He and Xe gases by spin-exchange collisions with optically pumped alkali-metal vapors. The most important physical processes considered are ~1! spin-conserving spin-exchange collisions between like or unlike alkali-metal atoms; ~2! spin-destroying collisions of the alkali-metal atoms with each other and with buffer-gas atoms; ~3!...

متن کامل

Optical pumping magnetic resonance in high magnetic fields: Characterization of nuclear relaxation during pumping

The polarization of Xe gas by spin exchange with optically pumped Rb vapor is investigated in high magnetic field. Operation in a high field provides added spectral dispersion via Zeeman shifts of the electronic transitions. This simplifies the physics of the pumping process in such a way as to make it more amenable to treatment with simple rate theory. A relationship between the steady state X...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014